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Maxwell Biotech Group currently has 9 biotech companies in its portfolio, which are engaged in the development of 11 innovative clinical stage drugs. 

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Maxwell Biotech Group

Q203

Q203

mbg-infectex-007Product: Q203 — is the first in new class of amide imidazopyridine compounds.

The therapeutic focus: pulmonary tuberculosis; perspective focus – extrapulmonary and generalized tuberculosis.

Status: phase 1 clinical trial

Partner: Qurient Co.

Description: 

The developed drug is a highly selective inhibitor of the growth of M. tuberculosis. The mechanism of action is implemented at the level of the cytochrome bc1complex (complex III) of the respiratory chain M.tuberculosis. Preclinical studies have showed:

  • Selectivity of action only against tuberculosis, both sensitive and drug-resistant clinical isolates
  • Efficacy in an animal model at micromolar concentrations
  • Low frequency of drug resistance of tuberculosis
  • Activity in latent tuberculosis
  • The favorable pharmacokinetic profile, which is important during long-term treatment

Development:

A phase 1 dose-escalation study to evaluate safety, tolerability and pharmacokinetics of single and multiple doses of Q203 in healthy volunteers have been started in March 2016.

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